In a 2023 review on cellulite, American plastic surgeon
Dr. Allen Gabriel and his research team systematically
summarized studies on topical caffeine, retinol, botanical extracts,
and massage therapy.
The team noted that caffeine and retinol are among the more extensively
studied ingredients used in topical cellulite-care formulations.
Caffeine may be associated with lipolytic pathways, local
microcirculation, and antioxidant activity.
Retinol, meanwhile, may help reduce the visible appearance of cellulite
by supporting dermal thickness, encouraging connective-tissue renewal,
and improving the overall structure and appearance of the skin.
Several randomized, placebo-controlled studies reviewed by the research
team observed visible improvements in cellulite severity with topical
formulations containing caffeine or retinol.